| Rathbone Investment Management |
23,447,505 |
£14,185,740 |
| Aberforth Partners LLP |
20,604,106 |
£12,465,484 |
| Aberforth Partners LLP |
18,989,817 |
£11,488,839 |
| Henderson Global Investors Ltd |
17,620,012 |
£10,660,107 |
| Montanaro Asset Management Limited |
11,531,638 |
£6,976,641 |
| Nortrust Nominees Ltd |
9,859,977 |
£5,965,286 |
| HSBC Holdings Plc |
9,558,166 |
£5,782,690 |
| Momentum Global Investment Management Ltd. |
9,385,993 |
£5,678,526 |
| The Wellcome Trust Limited |
9,385,811 |
£5,678,416 |
| Coltrane Asset Management, L.P. |
9,355,366 |
£5,659,996 |
| Dimensional Fund Advisors Inc. |
9,339,455 |
£5,650,370 |
| ClearBridge Investments, LLC |
9,307,805 |
£5,631,222 |
| The Capital Group Companies, Inc |
9,291,379 |
£5,621,284 |
| Aggregate of Standard Life Aberdeen plc |
9,228,860 |
£5,583,460 |
| Bayberry Capital Partners LP |
9,175,975 |
£5,551,465 |
| Sand Grove Capital Management |
8,456,440 |
£5,116,146 |
| Brewin Dolphin Limited |
8,392,338 |
£5,077,364 |
| The Wellcome Trust Limited |
7,970,207 |
£4,821,975 |
| Royal London Asset Management Limited |
6,794,023 |
£4,110,384 |
| Bradley Louis Radoff |
5,627,125 |
£3,404,411 |
| UBS Investment Bank |
5,444,969 |
£3,294,206 |