| Redmile Group, LLC |
297,188,365 |
£28,530,083 |
| Vulpes Investment Management Pte Ltd |
143,537,037 |
£13,779,556 |
| VULPES LIFE SCIENCES FUND |
140,387,037 |
£13,477,156 |
| VULPES LIFE SCIENCES FUND |
117,729,029 |
£11,301,987 |
| Ferlim Nominees Limited |
50,632,079 |
£4,860,680 |
| Reyker Nominees Ltd |
48,464,691 |
£4,652,610 |
| Hargreaves Lansdown |
33,619,839 |
£3,227,504 |
| Share Nominees Ltd. |
29,887,768 |
£2,869,226 |
| The Bank of New York Nominees Limited |
21,287,775 |
£2,043,626 |
| Legal & General Group Plc |
18,167,000 |
£1,744,032 |
| Nortrust Nominees Limited |
18,167,000 |
£1,744,032 |
| City Financial Investment Company Limited |
16,287,775 |
£1,563,626 |
| Barclayshare Nominees Ltd |
15,650,629 |
£1,502,460 |
| Lynchwood Nominees Ltd. |
15,085,721 |
£1,448,229 |
| Rock Nominees Limited |
13,445,702 |
£1,290,787 |
| Hygea VCT |
13,149,730 |
£1,262,374 |
| Huntress Nominees (CI) Limited |
11,309,220 |
£1,085,685 |
| Layton Trustees & L.G. Durrant |
8,773,960 |
£842,300 |
| JG Helfenstein |
7,000,000 |
£672,000 |