| Rathbone Investment Management |
23,447,505 |
£15,217,431 |
| Aberforth Partners LLP |
20,604,106 |
£13,372,065 |
| Aberforth Partners LLP |
18,989,817 |
£12,324,391 |
| Henderson Global Investors Ltd |
17,620,012 |
£11,435,388 |
| Montanaro Asset Management Limited |
11,531,638 |
£7,484,033 |
| Nortrust Nominees Ltd |
9,859,977 |
£6,399,125 |
| HSBC Holdings Plc |
9,558,166 |
£6,203,250 |
| Momentum Global Investment Management Ltd. |
9,385,993 |
£6,091,510 |
| The Wellcome Trust Limited |
9,385,811 |
£6,091,391 |
| Coltrane Asset Management, L.P. |
9,355,366 |
£6,071,632 |
| Dimensional Fund Advisors Inc. |
9,339,455 |
£6,061,306 |
| ClearBridge Investments, LLC |
9,307,805 |
£6,040,765 |
| The Capital Group Companies, Inc |
9,291,379 |
£6,030,105 |
| Aggregate of Standard Life Aberdeen plc |
9,228,860 |
£5,989,530 |
| Bayberry Capital Partners LP |
9,175,975 |
£5,955,208 |
| Sand Grove Capital Management |
8,456,440 |
£5,488,230 |
| Brewin Dolphin Limited |
8,392,338 |
£5,446,627 |
| The Wellcome Trust Limited |
7,970,207 |
£5,172,664 |
| Royal London Asset Management Limited |
6,794,023 |
£4,409,321 |
| Bradley Louis Radoff |
5,627,125 |
£3,652,004 |
| UBS Investment Bank |
5,444,969 |
£3,533,785 |