| The Bank of New York (Nominees) Limited |
87,763,271 |
£61,609,816 |
| Harwood Capital LLP |
70,315,021 |
£49,361,145 |
| AstraZeneca PLC |
66,093,108 |
£46,397,362 |
| Nortrust Nominees Limited |
58,832,384 |
£41,300,334 |
| State Street Nominees Limited |
51,334,357 |
£36,036,719 |
| Imperial Innovations Businesses LLP |
47,355,417 |
£33,243,503 |
| Rathbones Investment Management Ltd |
41,753,708 |
£29,311,103 |
| Chase (GA Group) Nominees Limited |
36,606,654 |
£25,697,871 |
| Oryx International Growth Fund Limited |
30,000,000 |
£21,060,000 |
| PH Nominees Limited |
28,324,296 |
£19,883,656 |
| Chase Nominees Limited |
23,185,617 |
£16,276,303 |
| Charles Stanley Group Plc |
21,045,925 |
£14,774,239 |
| Raymond James Wealth Management Limited |
20,866,227 |
£14,648,091 |
| Lombard Odier Asset Management (Europe) Limited |
18,133,419 |
£12,729,660 |
| Neptune Investment Management Limited |
17,909,985 |
£12,572,810 |
| Invesco Limited |
15,660,000 |
£10,993,320 |
| Danske Bank A/S |
13,235,132 |
£9,291,063 |
| CIP Merchant Capital Limited |
12,800,000 |
£8,985,600 |
| Odey Asset Management LLP |
12,688,236 |
£8,907,142 |
| Lansdowne Partners International Limited |
7,893,712 |
£5,541,386 |