| Rathbone Investment Management |
23,447,505 |
£15,334,668 |
| Aberforth Partners LLP |
20,604,106 |
£13,475,085 |
| Aberforth Partners LLP |
18,989,817 |
£12,419,340 |
| Henderson Global Investors Ltd |
17,620,012 |
£11,523,488 |
| Montanaro Asset Management Limited |
11,531,638 |
£7,541,691 |
| Nortrust Nominees Ltd |
9,859,977 |
£6,448,425 |
| HSBC Holdings Plc |
9,558,166 |
£6,251,041 |
| Momentum Global Investment Management Ltd. |
9,385,993 |
£6,138,439 |
| The Wellcome Trust Limited |
9,385,811 |
£6,138,320 |
| Coltrane Asset Management, L.P. |
9,355,366 |
£6,118,409 |
| Dimensional Fund Advisors Inc. |
9,339,455 |
£6,108,004 |
| ClearBridge Investments, LLC |
9,307,805 |
£6,087,304 |
| The Capital Group Companies, Inc |
9,291,379 |
£6,076,562 |
| Aggregate of Standard Life Aberdeen plc |
9,228,860 |
£6,035,674 |
| Bayberry Capital Partners LP |
9,175,975 |
£6,001,088 |
| Sand Grove Capital Management |
8,456,440 |
£5,530,512 |
| Brewin Dolphin Limited |
8,392,338 |
£5,488,589 |
| The Wellcome Trust Limited |
7,970,207 |
£5,212,515 |
| Royal London Asset Management Limited |
6,794,023 |
£4,443,291 |
| Bradley Louis Radoff |
5,627,125 |
£3,680,140 |
| UBS Investment Bank |
5,444,969 |
£3,561,010 |