| North London Ventures Limited |
243,461,685 |
£231,288,601 |
| The Wellcome Trust |
186,000,000 |
£176,700,000 |
| BlackRock, Inc. |
58,906,849 |
£55,961,506 |
| Schroders plc |
33,488,292 |
£31,813,877 |
| Smith and Williamson Holdings Limited |
32,849,272 |
£31,206,808 |
| Waverton Investment Management Limited |
31,640,760 |
£30,058,722 |
| Sarasin & Partners LLP |
30,934,159 |
£29,387,451 |
| Legal & General Group Plc (Group) |
26,834,153 |
£25,492,445 |
| J O Hambro Investment Management Limited |
23,218,940 |
£22,057,993 |
| RATHBONE BROTHERS PLC |
22,583,470 |
£21,454,296 |
| Cazenove Capital Management Limited |
20,177,500 |
£19,168,625 |
| Bestinvest (Brokers) Limited |
19,649,263 |
£18,666,800 |
| J.M. FINN & CO LTD |
19,181,655 |
£18,222,572 |
| Bestinvest (Brokers) Limited |
18,125,820 |
£17,219,529 |
| Royal Bank of Canada |
10,621,570 |
£10,090,492 |