| Rathbone Investment Management |
23,447,505 |
£14,936,061 |
| Aberforth Partners LLP |
20,604,106 |
£13,124,816 |
| Aberforth Partners LLP |
18,989,817 |
£12,096,513 |
| Henderson Global Investors Ltd |
17,620,012 |
£11,223,948 |
| Montanaro Asset Management Limited |
11,531,638 |
£7,345,653 |
| Nortrust Nominees Ltd |
9,859,977 |
£6,280,805 |
| HSBC Holdings Plc |
9,558,166 |
£6,088,552 |
| Momentum Global Investment Management Ltd. |
9,385,993 |
£5,978,878 |
| The Wellcome Trust Limited |
9,385,811 |
£5,978,762 |
| Coltrane Asset Management, L.P. |
9,355,366 |
£5,959,368 |
| Dimensional Fund Advisors Inc. |
9,339,455 |
£5,949,233 |
| ClearBridge Investments, LLC |
9,307,805 |
£5,929,072 |
| The Capital Group Companies, Inc |
9,291,379 |
£5,918,608 |
| Aggregate of Standard Life Aberdeen plc |
9,228,860 |
£5,878,784 |
| Bayberry Capital Partners LP |
9,175,975 |
£5,845,096 |
| Sand Grove Capital Management |
8,456,440 |
£5,386,752 |
| Brewin Dolphin Limited |
8,392,338 |
£5,345,919 |
| The Wellcome Trust Limited |
7,970,207 |
£5,077,022 |
| Royal London Asset Management Limited |
6,794,023 |
£4,327,793 |
| Bradley Louis Radoff |
5,627,125 |
£3,584,479 |
| UBS Investment Bank |
5,444,969 |
£3,468,445 |